TB-500

Description

DESCRIPTION

TB-500 (Thymosin Beta-4 Fragment) is a synthetic research peptide derived from the active region of the naturally occurring Thymosin Beta-4 protein. It is widely studied for its roles in actin regulation, cytoskeletal repair, fibroblast migration, angiogenesis, and tissue-regeneration pathways. Laboratory models explore its effects in musculoskeletal recovery, wound healing, cardiovascular repair, and cellular-protection studies.

LYOPHILIZED PEPTIDES

This peptide is supplied as a sterile, lyophilized powder to maintain molecular stability, purity, and long-term integrity. No fillers or excipients are added.

RESEARCH APPLICATIONS

1 — Wound Healing & Tissue Regeneration

TB-500 is studied for its role in promoting keratinocyte migration, angiogenesis, and accelerated wound-closure processes. Researchers analyze its effects on cellular migration and vascular remodeling.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/16400324/, Nature—https://www.nature.com/articles/s41598-017-12189-1 )

2 — Muscle, Tendon & Ligament Repair

Through regulation of actin polymerization and cytoskeletal stabilization, TB-500 is used in models investigating muscle-fiber regeneration, tendon repair, and connective-tissue recovery.

(References: ScienceDirect—https://www.sciencedirect.com/science/article/pii/S0944711319302200, PubMed—https://pubmed.ncbi.nlm.nih.gov/17984136/ )

3 — Cardiovascular & Neurological Studies

TB-500 has been evaluated in laboratory systems for cardiac cell-regeneration potential, vascular repair activity, and exploratory neuroprotective signaling effects.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/22172416/, Frontiers—https://www.frontiersin.org/articles/10.3389/fphar.2021.808770/full )

SPECIFICATIONS

Property | Details

Peptide Name | TB-500 (Thymosin Beta-4 Fragment)

Amino Acid Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Ser-Val

CAS Number | 77591-33-4

Molecular Formula | C212H350N56O78S

Molecular Weight | 4963.49 g/mol

Purity | ≥ 99% (HPLC verified)

Appearance | White to off-white lyophilized powder

Solubility | Soluble in bacteriostatic/sterile water

Storage | Store dry at 2–8 °C; refrigerate ≤ 30 days after reconstitution

Usage | Laboratory research only

Research Data & References

– Wound healing & angiogenesis: https://pubmed.ncbi.nlm.nih.gov/16400324/

– Muscle & tendon repair: https://pubmed.ncbi.nlm.nih.gov/17984136/

– Cardiovascular & neurological studies: https://pubmed.ncbi.nlm.nih.gov/22172416/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice. Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards. EOC Labs supports responsible, ethical, and compliant scientific inquiry.