Description

PT-141 (Bremelanotide)

Overview

PT-141, also known as Bremelanotide, is a synthetic cyclic peptide derived from the melanocortin peptide Melanotan II. It functions as a melanocortin receptor agonist and is studied in laboratory research examining central nervous system signaling pathways associated with melanocortin receptor activity.

The compound interacts primarily with melanocortin receptor subtypes within the melanocortin receptor family, including MC3R and MC4R, which are involved in neuroendocrine signaling and central regulatory pathways. In experimental models, PT-141 is used to investigate melanocortin-mediated signaling mechanisms within the central nervous system.

Mechanism of Action

PT-141 acts as an agonist of melanocortin receptors, particularly MC3R and MC4R. These receptors belong to the G protein–coupled receptor (GPCR) family and participate in intracellular signaling pathways mediated by cyclic AMP (cAMP).

Experimental mechanisms investigated include:

• Activation of melanocortin receptor subtypes MC3R and MC4R
• GPCR-mediated signaling pathways involving cyclic AMP (cAMP)
• Central nervous system melanocortin signaling research
• Neuroendocrine signaling pathway investigation involving melanocortin receptor systems

In research environments, PT-141 serves as a molecular probe for studying melanocortin receptor signaling and downstream intracellular pathways associated with GPCR-mediated neuronal communication.

Research Applications

• Melanocortin receptor signaling research
• G protein–coupled receptor (GPCR) pathway investigation
• Central nervous system peptide signaling studies
• Neuroendocrine signaling pathway modeling
• Experimental research involving melanocortin receptor activation

Chemical & Molecular Specifications

Compound Name: PT-141

Alternative Name: Bremelanotide

Peptide Type: Synthetic cyclic melanocortin receptor agonist

Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Molecular Formula: C50H68N14O10

Molecular Weight: 1025.18 g/mol

CAS Number: 189691-06-3

Typical Analytical Purity: ≥99% (HPLC)

Analytical Verification Methods: High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)

Lyophilized Peptide

PT-141 is supplied in lyophilized (freeze-dried) form to support molecular stability during storage and transport. Lyophilization removes water under controlled conditions, helping preserve peptide structure and integrity prior to reconstitution. This format allows for accurate handling and preparation within laboratory research environments.

Storage & Handling (Research Use Only)

• Store lyophilized material at −20 °C or below unless otherwise specified by laboratory protocol.
• Following reconstitution, short-term storage at 2–8 °C is recommended.
• Protect from light and temperature extremes.
• Avoid repeated freeze–thaw cycles.
• Handle using appropriate sterile laboratory techniques and institutional safety procedures.

References

PubChem – Bremelanotide compound record

NCBI – Melanocortin receptor signaling overview

ScienceDirect – Melanocortin receptor researc

Research Disclaimer

RESEARCH USE ONLY.
This product is not intended for therapeutic or diagnostic use. EOC Labs products are sold strictly for laboratory research and analytical purposes only. All information provided by EOC Labs, including descriptions, references, and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made for any medical or consumer application. By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.