Sermorelin

Description

DESCRIPTION

Sermorelin is a synthetic 29–amino‑acid fragment of Growth Hormone–Releasing Hormone (GHRH 1‑29), extensively used in laboratory research to study pituitary GH stimulation, hypothalamic regulatory signaling, endocrine feedback loops, and age‑related changes in GH secretion. Studies explore its influence on GH/IGF‑1 pathways, pulsatile secretion dynamics, and metabolic/endocrine response models under controlled experimental conditions.

LYOPHILIZED PEPTIDES

This peptide is supplied as a sterile, freeze‑dried (lyophilized) powder to maintain purity, structural stability, and long‑term integrity. No fillers or excipients are added.

RESEARCH APPLICATIONS

1 — Pituitary GH Release & Endocrine Regulation

Sermorelin is widely used to investigate GHRH‑receptor activation, pulsatile GH release, IGF‑1 modulation, and endocrine‑axis modeling. Research evaluates its short‑acting properties and physiologic GH‑cycle behavior.

(References: Nature—https://www.nature.com/articles/ijo2013172, PubMed—https://pubmed.ncbi.nlm.nih.gov/2699646/ )

2 — Hypothalamic Signaling & Aging‑Related GH Decline

Studies examine how Sermorelin influences hypothalamic regulation, age‑related changes in GH rhythm, and neuroendocrine communication within the GH/IGF‑1 system.

(References: ScienceDirect—https://www.sciencedirect.com/science/article/pii/S0026049522001033, PubMed—https://pubmed.ncbi.nlm.nih.gov/24516338/ )

3 — Cellular Repair, Protein Synthesis & Metabolic Studies

Research models explore Sermorelin for its role in protein‑synthesis pathways, metabolic recovery, cellular‑repair signaling, and growth‑factor–related mechanisms.

(References: Frontiers—https://www.frontiersin.org/articles/10.3389/fendo.2021.791797/full, PubMed—https://pubmed.ncbi.nlm.nih.gov/17163493/ )

SPECIFICATIONS

Property | Details

Peptide Name | Sermorelin

Amino Acid Sequence | Tyr‑Ala‑Asp‑Ala‑Ile‑Phe‑Thr‑Asn‑Ser‑Tyr‑Arg‑Lys‑Val‑Leu‑Gly‑Gln‑Leu‑Ser‑Ala‑Arg‑Lys‑Leu‑Leu‑Gln‑Asp‑Ile‑Met‑Ser

Molecular Formula | C149H246N44O42S

Molecular Weight | ≈ 3358.0 g/mol

CAS Number | 86168‑78‑7

Purity | ≥ 99% (HPLC verified)

Appearance | White to off‑white lyophilized powder

Solubility | Soluble in sterile/bacteriostatic water

Storage | Store dry at 2–8 °C; refrigerate ≤ 30 days after reconstitution

Usage | Laboratory research only

Research Data & References

– GH secretion & pituitary activity: https://pubmed.ncbi.nlm.nih.gov/2699646/

– Endocrine modeling & GHRH studies: https://pubmed.ncbi.nlm.nih.gov/17163493/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice. Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards. EOC Labs supports responsible, ethical, and compliant scientific inquiry.