SEMAX

Description

DESCRIPTION

SEMAX is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro), derived from the ACTH(4–10) fragment, and widely studied for its roles in cognitive processes, neurotrophic modulation, neuroprotection, oxidative-stress regulation, and cerebral signaling pathways. Research models explore its influence on BDNF expression, synaptic plasticity, attention mechanisms, memory formation, and neuroendocrine stress-response systems. SEMAX is frequently used in controlled laboratory settings to investigate central nervous system adaptation and neurochemical regulatory functions.

LYOPHILIZED PEPTIDES

This peptide is supplied as a sterile, freeze‑dried (lyophilized) powder to maintain molecular stability, purity, and long‑term integrity. No fillers, carriers, or excipients are added during the lyophilization process.

RESEARCH APPLICATIONS

1 — Cognitive Enhancement & Memory Pathway Research

SEMAX has been evaluated for its effects on synaptic transmission, attention circuits, and memory‑related neuroplasticity. Research also explores its influence on BDNF expression and monoaminergic neurotransmission.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/21605582/, PubMed—https://pubmed.ncbi.nlm.nih.gov/15862918/, ScienceDirect—https://www.sciencedirect.com/science/article/pii/S0166432816305516 )

2 — Neuroprotection & Oxidative‑Stress Modulation

Laboratory models indicate SEMAX may support neuronal resilience through antioxidant‑enzyme regulation, anti‑inflammatory signaling, and attenuation of oxidative damage in stressed neural tissues.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/16181260/, PubMed—https://pubmed.ncbi.nlm.nih.gov/23113316/, Frontiers—https://www.frontiersin.org/articles/10.3389/fnins.2019.01129/full )

3 — Ischemic Injury & Stroke‑Recovery Modeling

SEMAX has been studied in controlled ischemic models for impacts on cerebral perfusion, neurofunctional recovery, neural stabilization, and adaptive responses following hypoxic injury.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/12796686/, PubMed—https://pubmed.ncbi.nlm.nih.gov/15932605/, Nature—https://www.nature.com/articles/s41598-017-12189-1 )

4 — Stress‑Response, Mood Pathways & Neuroendocrine Regulation

Research investigates SEMAX’s effects on stress‑adaptation pathways, neuroendocrine signaling, and neurotransmitter balance, including its influence on behavioral‑stress markers and emotional‑regulation circuits.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/18037588/, PubMed—https://pubmed.ncbi.nlm.nih.gov/20412448/, MDPI—https://www.mdpi.com/2076-3425/11/8/1030 )

SPECIFICATIONS

Property | Details

Peptide Name | SEMAX

Amino Acid Sequence | Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro (MEHFPGP)

Chemical Name | L‑methionyl‑L‑glutamyl‑L‑histidyl‑L‑phenylalanyl‑L‑prolyl‑glycyl‑L‑proline

CAS Number | 80714‑61‑0

Molecular Formula | C37H51N9O10

Molecular Weight | ~751.85 g/mol

Purity | ≥ 99% (HPLC verified)

Appearance | White to off‑white lyophilized powder

Solubility | Soluble in sterile/bacteriostatic water

Storage | Store dry at −20 °C; refrigerate ≤ 30 days after reconstitution

Usage | Laboratory research only

Research Data & References

– Cognitive signaling & BDNF modulation: https://pubmed.ncbi.nlm.nih.gov/21605582/

– Neuroprotection & oxidative‑stress research: https://pubmed.ncbi.nlm.nih.gov/23113316/

– Ischemic injury & cerebral recovery: https://pubmed.ncbi.nlm.nih.gov/15932605/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice. Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards. EOC Labs supports responsible, ethical, and compliant scientific inquiry.