NAD+

Description

DESCRIPTION

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential pyridine nucleotide that functions as a central cofactor in cellular energy metabolism, redox reactions, mitochondrial ATP production, DNA repair, sirtuin activation, and cellular-stress signaling. It plays a key role in pathways involving oxidative phosphorylation, PARP-dependent DNA-repair mechanisms, and age-related metabolic decline. Research applications include mitochondrial biology, neuroprotection, metabolic regulation, and genomic stability.

LYOPHILIZED PEPTIDES

This compound is provided in a lyophilized form to preserve structural integrity, purity, and long-term molecular stability. No fillers or excipients are used during lyophilization.

RESEARCH APPLICATIONS

1 — Mitochondrial Function & Cellular Energy Metabolism

NAD+ is widely studied for its role in mitochondrial oxidative phosphorylation, electron-transport-chain activity, and ATP synthesis. Research examines how NAD+ levels influence mitochondrial efficiency, metabolic flexibility, and cellular survival during stress.

(References: Nature—https://www.nature.com/articles/s41586-018-0645-6, PubMed—https://pubmed.ncbi.nlm.nih.gov/25738459/ )

2 — Sirtuin Activation, DNA Repair & Longevity Pathways

NAD+ is required for PARP-mediated DNA repair and sirtuin-dependent chromatin remodeling. Studies evaluate its effects on genomic stability, cellular senescence, epigenetic regulation, and aging-related biochemical pathways.

(References: ScienceDirect—https://www.sciencedirect.com/science/article/pii/S155041311630192X, PubMed—https://pubmed.ncbi.nlm.nih.gov/31578236/ )

3 — Neuroprotection & Oxidative-Stress Response

Research models show NAD+ involvement in neuronal survival, ischemia-response mechanisms, mitochondrial ROS regulation, and bioenergetic recovery pathways. NAD+-dependent enzymes are key components of neurological resilience.

(References: Frontiers—https://www.frontiersin.org/articles/10.3389/fncel.2018.00002/full, PubMed—https://pubmed.ncbi.nlm.nih.gov/33394327/ )

SPECIFICATIONS

Property | Details

Compound Name | Nicotinamide Adenine Dinucleotide (NAD+)

Chemical Class | Pyridine nucleotide cofactor

CAS Number | 53-84-9

Molecular Formula | C21H27N7O14P2

Molecular Weight | 663.43 g/mol

Appearance | White to off-white lyophilized powder

Purity | ≥ 99% (HPLC verified)

Solubility | Soluble in sterile/bacteriostatic water

Storage | Store dry at 2–8 °C; after reconstitution refrigerate ≤ 14 days

Usage | Laboratory research only

Research Data & References

– Mitochondrial activity & ATP regulation: https://pubmed.ncbi.nlm.nih.gov/25738459/

– DNA repair & sirtuin regulation: https://pubmed.ncbi.nlm.nih.gov/31578236/

– Neuroprotective oxidative-stress models: https://pubmed.ncbi.nlm.nih.gov/33394327/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice. Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards. EOC Labs supports responsible, ethical, and compliant scientific inquiry.