MOTS-C

Description

DESCRIPTION

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16–amino-acid mitochondrial-derived peptide extensively studied for its roles in metabolic regulation, AMPK activation, glucose utilization, insulin sensitivity, mitochondrial stress response, and adaptive cellular resilience. Research has explored its influence on exercise performance, oxidative stress pathways, mitochondrial gene expression, and bioenergetic homeostasis across a range of controlled laboratory models.

LYOPHILIZED PEPTIDES

This peptide is provided in lyophilized form to preserve purity, molecular stability, and long-term structural integrity. No fillers or excipients are used in the lyophilization process.

RESEARCH APPLICATIONS

1 — Metabolic Regulation & AMPK Activation

Studies show that MOTS-c may activate AMPK pathways, supporting improved glucose uptake, insulin sensitivity, and metabolic flexibility. Research models frequently examine its effects on mitochondrial signaling, nutrient-sensing pathways, and bioenergetic balance.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/25738459/, Nature—https://www.nature.com/articles/s41467-022-35804-2 )

2 — Exercise Physiology & Muscle Performance

Laboratory and preclinical research suggests MOTS-c may enhance endurance, muscular resilience, and adaptive responses to exercise-induced stress. Investigations include its role in mitochondrial biogenesis, ATP regulation, and cytoprotective mechanisms during training.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/36677050/, ScienceDirect—https://www.sciencedirect.com/science/article/pii/S2212877822001063 )

3 — Cellular Stress Response & Gene Regulation

MOTS-c is studied for its unique ability to translocate to the nucleus and regulate stress‑responsive genes, influencing mitochondrial–nuclear communication, antioxidant defenses, and adaptive protective pathways. Research explores its involvement in ROS modulation and mitochondrial resilience.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/38658141/, PubMed—https://pubmed.ncbi.nlm.nih.gov/33394327/ )

SPECIFICATIONS

Property | Details

Peptide Name | MOTS-c

Amino Acid Sequence | MRWQEMGYIFYPRKLR

Molecular Formula | C101H152N28O22S2

Molecular Weight | ≈ 2174.6 g/mol

CAS Number | 1627580-64-6

Purity | ≥ 99% (HPLC verified)

Appearance | White to off-white lyophilized powder

Solubility | Soluble in bacteriostatic water

Storage | Store dry at 2–8 °C; after reconstitution refrigerate ≤ 30 days

Usage | Laboratory research only

Research Data & References

– AMPK activation & metabolic function: https://pubmed.ncbi.nlm.nih.gov/25738459/

– Exercise physiology & endurance: https://pubmed.ncbi.nlm.nih.gov/36677050/

– Mitochondrial gene-regulation under stress: https://pubmed.ncbi.nlm.nih.gov/38658141/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice. Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards. EOC Labs supports responsible, ethical, and compliant scientific inquiry.