Description

DESCRIPTION

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16–amino-acid mitochondrial-derived peptide extensively studied for its roles in metabolic regulation, AMPK activation, glucose utilization, insulin sensitivity, mitochondrial stress response, and adaptive cellular resilience. Research has explored its influence on exercise performance, oxidative stress pathways, mitochondrial gene expression, and bioenergetic homeostasis across a range of controlled laboratory models.

LYOPHILIZED PEPTIDES

This peptide is provided in lyophilized form to preserve purity, molecular stability, and long-term structural integrity. No fillers or excipients are used in the lyophilization process.

RESEARCH APPLICATIONS

1 — Metabolic Regulation & AMPK Activation

Studies show that MOTS-c may activate AMPK pathways, supporting improved glucose uptake, insulin sensitivity, and metabolic flexibility. Research models frequently examine its effects on mitochondrial signaling, nutrient-sensing pathways, and bioenergetic balance.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/25738459/, Nature—https://www.nature.com/articles/s41467-022-35804-2 )

2 — Exercise Physiology & Muscle Performance

Laboratory and preclinical research suggests MOTS-c may enhance endurance, muscular resilience, and adaptive responses to exercise-induced stress. Investigations include its role in mitochondrial biogenesis, ATP regulation, and cytoprotective mechanisms during training.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/36677050/, ScienceDirect—https://www.sciencedirect.com/science/article/pii/S2212877822001063 )

3 — Cellular Stress Response & Gene Regulation

MOTS-c is studied for its unique ability to translocate to the nucleus and regulate stress‑responsive genes, influencing mitochondrial–nuclear communication, antioxidant defenses, and adaptive protective pathways. Research explores its involvement in ROS modulation and mitochondrial resilience.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/38658141/, PubMed—https://pubmed.ncbi.nlm.nih.gov/33394327/ )

SPECIFICATIONS

Property | Details

Peptide Name | MOTS-c

Amino Acid Sequence | MRWQEMGYIFYPRKLR

Molecular Formula | C101H152N28O22S2

Molecular Weight | ≈ 2174.6 g/mol

CAS Number | 1627580-64-6

Purity | ≥ 99% (HPLC verified)

Appearance | White to off-white lyophilized powder

Solubility | Soluble in bacteriostatic water

Storage | Store dry at 2–8 °C; after reconstitution refrigerate ≤ 30 days

Usage | Laboratory research only

Research Data & References

– AMPK activation & metabolic function: https://pubmed.ncbi.nlm.nih.gov/25738459/

– Exercise physiology & endurance: https://pubmed.ncbi.nlm.nih.gov/36677050/

– Mitochondrial gene-regulation under stress: https://pubmed.ncbi.nlm.nih.gov/38658141/

Research Disclaimer

RESEARCH USE ONLY.
This product is not intended for therapeutic or diagnostic use. EOC Labs products are sold strictly for laboratory research and analytical purposes only. All information provided by EOC Labs, including descriptions, references, and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made for any medical or consumer application. By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.