GHK-Cu

Description

DESCRIPTION

GHK‑Cu (Gly‑His‑Lys–Copper Complex) is a naturally occurring tripeptide widely studied for its roles in extracellular‑matrix modulation, dermal remodeling, antioxidant support, and cellular repair mechanisms. Research models demonstrate that GHK‑Cu may influence collagen synthesis, gene‑expression profiles, wound‑healing pathways, and microcirculatory stability. Its broad biochemical activity has made it a central peptide of interest in regenerative‑biology and cellular‑response research.

LYOPHILIZED PEPTIDES

This peptide is provided in freeze‑dried (lyophilized) form to preserve molecular stability, purity, and long‑term storage integrity. No fillers or excipients are used during lyophilization.

RESEARCH APPLICATIONS

1 — Collagen Synthesis & Extracellular‑Matrix Remodeling

GHK‑Cu has been shown in laboratory research to upregulate collagen I, III, and IV, stimulate fibronectin, and enhance ECM repair in both dermal and connective‑tissue models. Its gene‑expression influence spans more than 4,000 human genes related to tissue regeneration and cellular signaling.

(References: MDPI—https://www.mdpi.com/1422-0067/19/4/1078, Nature—https://www.nature.com/articles/s41598-017-12189-1, PubMed—https://pubmed.ncbi.nlm.nih.gov/29718284/ )

2 — Antioxidant Activity & Cellular Protection

GHK‑Cu has been studied for its ability to reduce oxidative stress, regulate inflammatory cytokines, and restore antioxidant enzyme balance in stressed tissues. Research suggests protective roles against free‑radical damage, environmental stressors, and mitochondrial dysfunction.

(References: ScienceDirect—https://www.sciencedirect.com/science/article/pii/S0022283616303225, PubMed—https://pubmed.ncbi.nlm.nih.gov/11257466/ )

3 — Wound Healing & Tissue Repair Models

Research demonstrates enhanced wound closure, angiogenesis support, keratinocyte migration, and granulation‑tissue formation with GHK‑Cu application in controlled laboratory environments. Its activity in modulating metalloproteinases and tissue‑restructuring enzymes positions it as a key model peptide in regenerative‑healing studies.

(References: Frontiers—https://www.frontiersin.org/articles/10.3389/fphar.2021.808770/full, PubMed—https://pubmed.ncbi.nlm.nih.gov/25950459/ )

SPECIFICATIONS

Property | Details

Peptide Name | GHK‑Cu (Copper Tripeptide‑1)

Amino Acid Sequence | Gly‑His‑Lys

Molecular Formula | C14H24N6O4 • Cu

Molecular Weight | ≈ 340.88 g/mol (peptide) / ≈ 403.9 g/mol (GHK‑Cu complex)

CAS Number | 89030‑95‑5

Purity | ≥ 99% (HPLC verified)

Appearance | Blue to blue‑green lyophilized powder

Solubility | Soluble in bacteriostatic/sterile water

Storage | Store dry at 2–8 °C; refrigerate ≤ 30 days after reconstitution

Usage | Laboratory research only

Research Data & References

– ECM & collagen research: https://www.mdpi.com/1422-0067/19/4/1078

– Antioxidant & anti‑inflammatory activity: https://pubmed.ncbi.nlm.nih.gov/11257466/

– Wound‑healing & tissue‑repair studies: https://pubmed.ncbi.nlm.nih.gov/25950459/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice. Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards. EOC Labs supports responsible, ethical, and compliant scientific inquiry.