BPC-157

Description

DESCRIPTION

BPC-157 (Body Protection Compound-157) is a stable 15–amino acid peptide extensively studied for its cytoprotective, angiogenic, and regenerative properties. Derived from a naturally occurring gastric protein sequence, it maintains stability under enzymatic and acidic stress, making it suitable for diverse laboratory research conditions. Investigations have explored its influence on microcirculation, collagen organization, fibroblast activity, and nitric-oxide modulation across musculoskeletal, gastrointestinal, vascular, and neural models.

LYOPHILIZED PEPTIDES

These peptides are supplied as a freeze‑dried (lyophilized) powder to preserve purity, molecular stability, and long‑term storage integrity. No fillers or excipients are added during the lyophilization process.

RESEARCH APPLICATIONS

1 — Gastrointestinal Integrity & Mucosal Stability

BPC‑157 has been researched for its ability to support gastric and intestinal lining integrity, stabilize epithelial junctions, and protect microcirculation under inflammatory, oxidative, and chemically induced stress. Models show accelerated healing of gastric lesions and restoration of mucosal barrier proteins. (References: ScienceDirect—https://www.sciencedirect.com/science/article/pii/S0944711320301540, PubMed—https://pubmed.ncbi.nlm.nih.gov/33135667/)

2 — Angiogenesis & Vascular Protection

Preclinical vascular studies indicate that BPC‑157 modulates VEGFR2–Akt–eNOS signaling, enhances endothelial repair, and restores vascular tone under ischemic conditions. Researchers frequently investigate its micro‑capillary growth potential and anti‑thrombotic behavior in models of impaired blood flow. (References: Nature—https://www.nature.com/articles/s41598-020-78676-8, PubMed—https://pubmed.ncbi.nlm.nih.gov/28324077/)

3 — Musculoskeletal & Connective Tissue Regeneration

Studies show increased fibroblast proliferation, improved collagen alignment, and accelerated repair of tendons, ligaments, and skeletal muscle fibers. BPC‑157 has been explored for its ability to enhance GH‑receptor expression and improve functional recovery following mechanical injury. (References: MDPI—https://www.mdpi.com/1422-0067/19/4/1078, PubMed—https://pubmed.ncbi.nlm.nih.gov/29385773/)

4 — Dermal & Wound Healing Applications

BPC‑157 demonstrates pro‑healing activity through enhanced keratinocyte migration, granulation‑tissue formation, and inflammatory cytokine modulation. Its activation of ERK1/2 and FAK‑paxillin cascades supports accelerated wound‑closure models and dermal‑layer regeneration. (References: PubMed—https://pubmed.ncbi.nlm.nih.gov/25950459/, ScienceDirect—https://www.sciencedirect.com/science/article/pii/S0753332219364422)

5 — Neurological & Ocular Research

Research suggests BPC‑157 may promote neuronal survival, preserve retinal thickness, and modulate nitric‑oxide regulation following ischemic or oxidative damage. Investigators evaluate its role in optic‑nerve protection and retinal microvascular stability. (References: Frontiers—https://www.frontiersin.org/articles/10.3389/fphar.2021.632295/full, PubMed—https://pubmed.ncbi.nlm.nih.gov/27677715/)

SPECIFICATIONS

Property | Details

Peptide Name | BPC‑157 (Body Protection Compound‑157)

Amino Acid Sequence | Gly‑Glu‑Pro‑Pro‑Pro‑Gly‑Lys‑Pro‑Ala‑Asp‑Asp‑Ala‑Gly‑Leu‑Val

Molecular Formula | C62H98N16O22

Molecular Weight | 1419.53 g/mol

CAS Number | 137525‑51‑0

Purity | ≥ 99% (HPLC verified)

Appearance | White lyophilized powder

Solubility | Soluble in bacteriostatic water

Storage | Store dry at 2–8 °C; refrigerate ≤ 30 days after reconstitution

Usage | Laboratory research only · Use standard protective protocols

Research Data & References

– Gastrointestinal mucosal protection: https://www.sciencedirect.com/science/article/pii/S0944711320301540

– Angiogenesis & endothelial repair: https://pubmed.ncbi.nlm.nih.gov/28324077/

– Musculoskeletal regeneration mechanisms: https://pubmed.ncbi.nlm.nih.gov/29385773/

– Dermal healing & cytokine modulation: https://pubmed.ncbi.nlm.nih.gov/25950459/

– Neurological/ocular models: https://www.frontiersin.org/articles/10.3389/fphar.2021.632295/full

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research.These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application.Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice.Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards.EOC Labs supports responsible, ethical, and compliant scientific inquiry.