AOD-9604

Description

DESCRIPTION

AOD-9604 is a synthetic C-terminal fragment of human growth hormone (hGH), representing residues 176–191 with an added N‑terminal tyrosine. Unlike full-length hGH, AOD‑9604 has been studied for selective lipolytic activity without stimulating IGF‑1. Research has explored its roles in adipocyte metabolism, β‑adrenergic–associated lipolysis, and metabolic regulation in preclinical and early clinical models.

LYOPHILIZED PEPTIDES

These peptides are freeze-dried to preserve purity, structural integrity, and long-term stability. No fillers or excipients are used during lyophilization.

RESEARCH APPLICATIONS

1 — Lipolysis & Adipocyte Metabolism

AOD‑9604 has been investigated for increasing fat oxidation and stimulating adipocyte lipolysis in obese mouse models. Research highlights its ability to mimic the lipolytic region of hGH without influencing IGF‑1 pathways. (References: Nature—https://www.nature.com/articles/ijo2013172, ScienceDirect—https://www.sciencedirect.com/science/article/pii/S0026049522001033, PubMed—https://pubmed.ncbi.nlm.nih.gov/11316798/ )

2 — Metabolic Regulation & Energy Balance

Preclinical studies suggest potential effects on metabolic rate, β‑oxidation, and glucose utilization. Investigators evaluate whether AOD‑9604 may modulate mitochondrial activity and energy homeostasis. (References: PubMed—https://pubmed.ncbi.nlm.nih.gov/11316798/, MDPI—https://www.mdpi.com/2218-273X/10/2/304 )

3 — Clinical Safety & Tolerability Studies

Human trials report favorable safety and tolerability profiles. While efficacy outcomes for weight modulation have been mixed, clinical literature provides valuable insights into pharmacokinetics, metabolic endpoints, and dosing-response behavior. (References: PubMed—https://pubmed.ncbi.nlm.nih.gov/23797832/, ScienceDirect—https://www.sciencedirect.com/science/article/pii/S1550413113001072 )

SPECIFICATIONS

Property | Details

Peptide Name | AOD‑9604

Amino Acid Sequence | Tyr‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe

Molecular Formula | C78H123N23O23S2

Molecular Weight | ≈ 1815.1 g/mol

CAS Number | 221231‑10‑3

Purity | ≥ 99% (HPLC verified)

Appearance | White to off‑white lyophilized powder

Solubility | Soluble in sterile/bacteriostatic water

Storage | Store dry at 2–8 °C; after reconstitution refrigerate ≤ 14 days

Usage | Laboratory research only

Research Data & References

– AOD‑9604 lipolytic pathway research: https://pubmed.ncbi.nlm.nih.gov/11316798/

– Mitochondrial/metabolic pathways: https://www.mdpi.com/2218-273X/10/2/304

– Clinical evaluations & safety data: https://pubmed.ncbi.nlm.nih.gov/23797832/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice.Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards.EOC Labs supports responsible, ethical, and compliant scientific inquiry.