Description

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3)

Overview

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic analog of native human IGF-1, modified by an arginine substitution at position 3 and an extended N-terminal peptide chain. These structural modifications are designed to reduce binding affinity to insulin-like growth factor binding proteins (IGFBPs) in experimental systems. IGF-1 LR3 is studied exclusively in laboratory research environments for its role in cellular growth signaling, receptor interaction models, and metabolic pathway analysis.

Mechanism of Action (Research Context)

In research models, IGF-1 LR3 is investigated for its interaction with the IGF-1 receptor (IGF-1R), a tyrosine kinase receptor involved in intracellular signaling cascades such as PI3K/Akt and MAPK pathways. These pathways are associated with cellular proliferation, differentiation, and metabolic regulation in experimental systems. Observed effects are model-dependent and remain investigational.

Research Applications

• IGF-1 receptor signaling pathway studies
• Cellular growth, proliferation, and differentiation models
• Protein synthesis and metabolic signaling research
• Muscle cell and tissue culture research models
• Molecular biology and receptor–ligand interaction analysis

Lyophilized Peptide Education

IGF-1 LR3 is supplied in a lyophilized (freeze-dried) format to support molecular stability during storage and transport. Lyophilization minimizes moisture content and helps preserve peptide integrity when stored under appropriate laboratory conditions.

Chemical & Molecular Specifications

Peptide Name: IGF-1 LR3
Full Name: Insulin-like Growth Factor-1 Long Arg3
Compound Type: Recombinant peptide analog
Amino Acid Length: 83

Met-Phe-Pro-Ala-Met-Pro-Leu-Leu-Ser-Leu-Phe-Val-Asn-Val-Thr-Tyr-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala

Amino Acid Sequence: Modified IGF-1 sequence with Arg3 substitution and N-terminal extension
Molecular Formula: C400H625N111O115S6
Average Molecular Weight: ~9111 Da
Monoisotopic Mass (Major Peak): ~9109 Da
Purity: ≥99%

Storage & Handling (Research Use Only)

Store at −20 °C or below long term. Avoid repeated freeze–thaw cycles. Handle using appropriate laboratory safety protocols. After reconstitution store at 2-8°C (Refrigerate)

References (Research Literature)

1. PubChem – Insulin-like Growth Factor I
https://pubchem.ncbi.nlm.nih.gov/compound/Insulin-like-growth-factor-I

2. Jones & Clemmons, Insulin-like growth factors and binding proteins
https://pubmed.ncbi.nlm.nih.gov/10976090/

3. LeRoith et al., IGF-1 receptor signaling pathways
https://pubmed.ncbi.nlm.nih.gov/12679333/

4. Pollak M., Insulin and IGF signaling in biology
https://pubmed.ncbi.nlm.nih.gov/16597627/

Research Disclaimer

RESEARCH USE ONLY.
This product is not intended for therapeutic or diagnostic use. EOC Labs products are sold strictly for laboratory research and analytical purposes only. All information provided by EOC Labs, including descriptions, references, and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made regarding safety, efficacy, or suitability for any medical or consumer application. By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.