Description

Kisspeptin‑1 (Metastin)

Overview

Kisspeptin‑1 is a peptide encoded by the KISS1 gene and is a ligand for the G protein–coupled receptor KISS1R (also known as GPR54). The peptide family derived from the KISS1 precursor includes several active fragments such as Kisspeptin‑54, Kisspeptin‑14, Kisspeptin‑13, and Kisspeptin‑10. These peptides are studied in laboratory research examining neuroendocrine signaling pathways involved in hypothalamic regulation and reproductive hormone signaling.

In experimental biological systems, Kisspeptin signaling is investigated for its role in regulation of gonadotropin‑releasing hormone (GnRH) neurons within the hypothalamus. Activation of the KISS1R receptor initiates intracellular signaling cascades involved in neuroendocrine communication and hypothalamic‑pituitary‑gonadal (HPG) axis regulation.

Kisspeptin Research Highlights

• Signals the brain to release reproductive hormones
• Studied for GnRH neuron activation
• Research on reproductive hormone pathways
• Investigated for hypothalamic signaling
• Helps regulate endocrine communication

Mechanism of Action

Kisspeptin peptides function as endogenous ligands for the KISS1R (GPR54) receptor, a G protein–coupled receptor expressed in hypothalamic neurons that regulate gonadotropin‑releasing hormone signaling.

Experimental signaling mechanisms investigated include:

• Activation of KISS1R (GPR54) receptor signaling
• G protein–coupled receptor intracellular signaling pathways
• Stimulation of hypothalamic gonadotropin‑releasing hormone (GnRH) neuronal activity
• Investigation of hypothalamic–pituitary–gonadal (HPG) axis signaling pathways

Research Applications

• Neuroendocrine signaling pathway research
• Hypothalamic GnRH neuron activation studies
• Reproductive hormone signaling research
• G protein–coupled receptor (GPCR) signaling studies
• Experimental investigation of hypothalamic‑pituitary‑gonadal axis regulation

Chemical & Molecular Specifications

Compound Name: Kisspeptin‑1

Alternative Name: Metastin

Peptide Family: Kisspeptin peptides derived from the KISS1 precursor protein

Common Research Form: Kisspeptin‑54 (54 amino acids) or shorter active fragments such as Kisspeptin‑10

Receptor Target: KISS1R (GPR54)

Peptide Type: Endogenous neuroendocrine signaling peptide

Typical Analytical Purity: ≥99% (HPLC)

Analytical Verification Methods: High‑Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)

Lyophilized Peptide

Kisspeptin peptides are supplied in lyophilized (freeze‑dried) form to support molecular stability during storage and transport. Lyophilization removes water under controlled conditions, helping preserve peptide structure and integrity prior to reconstitution. This format allows precise handling and preparation in laboratory research environments.

Storage & Handling (Research Use Only)

• Store lyophilized material at −20 °C or below unless otherwise specified by laboratory protocol.
• Following reconstitution, short‑term storage at 2–8 °C is recommended.
• Protect from light and temperature extremes.
• Avoid repeated freeze–thaw cycles.
• Handle using appropriate sterile laboratory techniques and institutional safety procedures.

References

PubMed – Kisspeptin and GPR54 receptor signaling

NCBI – Kisspeptin control of GnRH neurons

ScienceDirect – Kisspeptin signaling overview

Research Disclaimer

RESEARCH USE ONLY.
This product is not intended for therapeutic or diagnostic use. EOC Labs products are sold strictly for laboratory research and analytical purposes only. All information provided by EOC Labs, including descriptions, references, and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made for any medical or consumer application. By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.