Description

Thymosin Alpha-1 (TA-1)

Overview

Thymosin Alpha-1 (TA-1) is a naturally occurring peptide originally isolated from thymus tissue. It consists of 28 amino acids and is studied in laboratory research as a regulator of immune-related cell signaling pathways. In experimental systems, TA-1 is used as a molecular probe to investigate immune cell activation, cytokine signaling dynamics, and mechanisms associated with adaptive and innate immune system regulation.

Research investigations examine the role of Thymosin Alpha-1 in cellular communication pathways involving T lymphocyte function, antigen presentation mechanisms, and signaling interactions within immune regulatory networks. Due to its defined structure and biological origin, the peptide is widely used in experimental immunology and molecular biology studies.

Mechanism of Action

In laboratory research models, Thymosin Alpha-1 has been investigated for its ability to influence immune signaling pathways involved in T-cell differentiation and activation. Experimental evidence suggests the peptide may interact with toll-like receptor (TLR) signaling systems and downstream pathways involved in cytokine production and immune cell communication.

Studies also examine TA-1 in the context of dendritic cell maturation and antigen presentation mechanisms. Activation of these pathways may influence intracellular signaling cascades associated with immune regulation, including pathways involving nuclear factor-kappa B (NF-κB) and other transcriptional regulators relevant to immune cell function.

Research Applications

• Immune signaling pathway investigations
• T lymphocyte activation studies
• Cytokine signaling research
• Dendritic cell maturation models
• Molecular immunology and immune communication studies

Chemical & Molecular Specifications

Compound name: Thymosin Alpha-1

Alternative name: TA-1

Peptide class: Thymic peptide hormone fragment

Sequence length: 28 amino acids

Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

Molecular formula: C129H215N33O55

Molecular weight: 3108.29 g/mol

Mono-isotopic mass: 3106.54 Da

CAS number: 62304-98-7

Typical analytical purity: ≥99%

Lyophilized Peptide

This peptide is supplied in lyophilized (freeze-dried) form to support molecular stability during storage and transport. Lyophilization removes water under controlled conditions, helping preserve peptide structure and integrity prior to reconstitution for laboratory research applications.

Storage & Handling (Research Use Only)

• Store lyophilized material at -20°C or below unless otherwise specified by laboratory protocol.
• Following reconstitution, short-term storage at 2–8°C is recommended.
• Protect from light and temperature extremes.
• Avoid repeated freeze-thaw cycles.
• Handle using appropriate sterile laboratory techniques and institutional safety procedures.

References (Research Literature)

PubMed – Thymosin Alpha-1 immunological mechanisms

PubMed – Thymosin Alpha-1 immune modulation studies

PubChem – Thymosin Alpha-1 compound data

ScienceDirect – thymic peptides and immune signaling

Research Disclaimer

RESEARCH USE ONLY.
This product is not intended for therapeutic or diagnostic use. EOC Labs products are sold strictly for laboratory research and analytical purposes only. All information provided by EOC Labs, including descriptions, references, and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made for any medical or consumer application. By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.