Description

DSIP (Delta Sleep–Inducing Peptide)

Overview

Delta Sleep–Inducing Peptide (DSIP) is a naturally occurring neuropeptide consisting of nine amino acids first isolated during investigations into sleep physiology and neuroendocrine regulation. The peptide has been studied in experimental neuroscience models examining circadian rhythm modulation, neuropeptide signaling, and hypothalamic regulatory pathways.

In laboratory research environments, DSIP is used as a molecular probe for investigating peptide-mediated communication within the central nervous system. Experimental models examine DSIP in relation to sleep-stage architecture, stress-response signaling pathways, and neuroendocrine regulatory systems involving hypothalamic–pituitary axis signaling.

Mechanism of Action

The precise receptor target responsible for DSIP signaling has not been definitively identified. However, experimental research suggests that DSIP interacts with multiple neurochemical systems involved in sleep regulation and neuroendocrine signaling.

Experimental mechanisms investigated include:

• Modulation of hypothalamic regulatory centers associated with circadian rhythm control
• Interaction with neurotransmitter systems including GABAergic and glutamatergic signaling pathways
• Influence on hypothalamic–pituitary–adrenal (HPA) axis signaling involved in stress-response regulation
• Investigation of peptide-mediated signaling involved in neuronal activity during delta-wave sleep phases

Research Applications

• Sleep architecture and circadian rhythm research
• Neuropeptide signaling pathway investigation
• Hypothalamic–pituitary axis research
• Central nervous system peptide signaling studies
• Experimental models examining neuroendocrine regulatory pathways

Chemical & Molecular Specifications

Compound Name: Delta Sleep–Inducing Peptide

Abbreviation: DSIP

Peptide Type: Endogenous neuropeptide (synthetic research analogue)

Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Sequence Length: 9 amino acids

Molecular Formula: C35H48N10O15

Molecular Weight: 848.81 g/mol

CAS Number: 62568-57-4

Typical Analytical Purity: ≥99% (HPLC)

Analytical Verification Methods: High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)

Lyophilized Peptide

DSIP is supplied in lyophilized (freeze-dried) form to support molecular stability during storage and transport. Lyophilization removes water under controlled conditions, helping preserve peptide structure and integrity prior to reconstitution. This format allows precise handling and preparation in laboratory research environments.

Storage & Handling (Research Use Only)

• Store lyophilized material at −20 °C or below unless otherwise specified by laboratory protocol.
• Following reconstitution, short-term storage at 2–8 °C is recommended.
• Protect from light and temperature extremes.
• Avoid repeated freeze–thaw cycles.
• Handle using appropriate sterile laboratory techniques and institutional safety procedures.

References

PubMed – Delta Sleep-Inducing Peptide research overview

PubMed – Neuroendocrine effects of DSIP

ScienceDirect – DSIP neuropeptide research overview

PubChem – Delta Sleep-Inducing Peptide compound record

Research Disclaimer

RESEARCH USE ONLY.
This product is not intended for therapeutic or diagnostic use. EOC Labs products are sold strictly for laboratory research and analytical purposes only. All information provided by EOC Labs, including descriptions, references, and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made for any medical or consumer application. By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.