SS-31

Description

DESCRIPTION

SS-31 (Elamipretide) is a mitochondria-targeting tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂) extensively researched for its role in mitochondrial stabilization, cardiolipin interaction, electron-transport-chain optimization, and protection against oxidative stress. Studies explore its effects on ATP generation, mitochondrial membrane integrity, cellular resilience, and bioenergetic performance across cardiac, neural, muscular, and metabolic research models.

LYOPHILIZED PEPTIDES

This peptide is supplied in sterile, freeze-dried (lyophilized) form to preserve purity, molecular stability, and long-term integrity. No fillers or excipients are added.

RESEARCH APPLICATIONS

1 — Mitochondrial Stabilization & Bioenergetic Function

SS-31 is widely studied for binding to cardiolipin in the inner mitochondrial membrane, helping stabilize electron transport, reduce ROS production, and improve ATP output. Research examines its role in supporting mitochondrial efficiency under metabolic or oxidative stress.

(References: PubMed—https://pubmed.ncbi.nlm.nih.gov/25738459/, Nature—https://www.nature.com/articles/s41467-022-35804-2 )

2 — Oxidative-Stress Reduction & Cellular Protection

Laboratory models show SS-31 may mitigate oxidative damage, support antioxidant enzyme function, and regulate mitochondrial stress-response pathways. It is commonly used in research on cellular resilience and injury-response modeling.

(References: ScienceDirect—https://www.sciencedirect.com/science/article/pii/S2212877822001063, PubMed—https://pubmed.ncbi.nlm.nih.gov/23113316/ )

3 — Cardiac, Neural & Muscular Research Models

SS-31 has been evaluated in models of cardiac tissue stress, skeletal muscle fatigue, neurodegeneration, and metabolic decline. Its mitochondrial-targeting activity allows for detailed study of tissue-specific energetic and protective pathways.

(References: Frontiers—https://www.frontiersin.org/articles/10.3389/fnins.2019.01129/full, PubMed—https://pubmed.ncbi.nlm.nih.gov/36677050/ )

SPECIFICATIONS

Property | Details

Peptide Name | SS-31 (Elamipretide)

Amino Acid Sequence | D-Arg-Dmt-Lys-Phe-NH₂

Molecular Formula | C34H56N10O5

Molecular Weight | ~748.9 g/mol

CAS Number | 127463-70-5

Purity | ≥ 99% (HPLC verified)

Appearance | White to off-white lyophilized powder

Solubility | Soluble in bacteriostatic/sterile water

Storage | Store dry at 2–8 °C; refrigerate ≤ 30 days after reconstitution

Usage | Laboratory research only

Research Data & References

– Mitochondrial biogenesis & ATP support: https://pubmed.ncbi.nlm.nih.gov/25738459/

– Oxidative-stress and protective signaling: https://pubmed.ncbi.nlm.nih.gov/23113316/

– Tissue-specific mitochondrial studies: https://pubmed.ncbi.nlm.nih.gov/36677050/

Disclaimer — Research Use Only

All information presented herein is intended solely for laboratory and educational research. These materials are not approved for human or veterinary use, nor for diagnostic or therapeutic application. Descriptions of biochemical activity are provided for informational context only and must not be interpreted as medical advice. Researchers are expected to handle all compounds in compliance with local regulations and institutional safety standards. EOC Labs supports responsible, ethical, and compliant scientific inquiry.