Description

Melanotan-1 (MT-1)

Overview

Melanotan-1 (MT-1), also known as Afamelanotide, is a synthetic analogue of the endogenous peptide hormone α-melanocyte-stimulating hormone (α-MSH). The compound is studied in molecular biology and receptor signaling research as a ligand for melanocortin receptor pathways. Laboratory investigations examine MT-1 interactions with melanocortin receptors involved in cellular signaling processes associated with pigmentation regulation and related receptor-mediated pathways.

In experimental systems, MT-1 is used as a research compound to study melanocortin receptor activation, peptide-receptor binding dynamics, and downstream intracellular signaling mechanisms. Its structural similarity to α-MSH allows it to serve as a useful model peptide for evaluating melanocortin receptor activity in controlled laboratory environments.

Mechanism of Action

Melanotan-1 is investigated primarily for its interaction with melanocortin receptors, particularly the MC1R receptor, which plays a central role in melanocyte signaling pathways.

In receptor-binding models, MT-1 acts as a melanocortin receptor agonist capable of activating signaling cascades associated with melanocyte stimulation. Activation of MC1R receptors can initiate intracellular signaling through cyclic AMP (cAMP) pathways that regulate transcriptional processes involved in melanin production within melanocyte cells.

Experimental research evaluates MT-1 as a tool compound for studying melanocortin receptor signaling mechanisms and peptide-mediated receptor activation. Observed cellular responses depend on experimental conditions and remain investigational within laboratory research systems.

Research Applications

• Melanocortin receptor signaling studies
• MC1R receptor activation models
• Peptide–receptor binding investigations
• Cellular pigmentation pathway research
• Molecular biology studies involving α-MSH analogues

Chemical & Molecular Specifications

Compound name: Melanotan-1

Alternative name: Afamelanotide

CAS number: 75921-69-6

Compound type: Synthetic peptide analogue of α-MSH

Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

Molecular formula: C78H111N21O19

Molecular weight: 1646.85 g/mol

Mono-isotopic mass: 1645.85 Da

Purity: ≥99%

Lyophilized Peptide

This peptide is supplied in lyophilized (freeze-dried) form to support molecular stability during storage and transport. Lyophilization removes water under controlled conditions, helping preserve peptide structure and integrity prior to reconstitution. This format allows for precise handling and preparation in laboratory research environments.

Storage & Handling (Research Use Only)

• Store lyophilized material at -20°C or below unless otherwise specified by laboratory protocol.
• Following reconstitution, short-term storage at 2–8°C is recommended.
• Protect from light and temperature extremes.
• Avoid repeated freeze-thaw cycles.
• Handle using appropriate sterile laboratory techniques and institutional safety procedures.

References (Research Literature)

PubMed (Afamelanotide and melanocortin receptor activity)

PubMed (α-MSH receptor signaling mechanisms)

PubChem (Afamelanotide compound data)

ScienceDirect (melanocortin receptor signaling overview)

Research Disclaimer (EOC Labs)

RESEARCH USE ONLY.
This product is not intended for therapeutic, diagnostic, or clinical use.It is not a drug, food, cosmetic, or dietary supplement. EOC Labs products are sold strictly for laboratory research and analytical purposes only.

All information provided by EOC Labs, including descriptions, references and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made regarding safety, efficacy, or suitability for any medical or consumer application.

By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.