Description

KPV (Lys‑Pro‑Val)

Overview

KPV is a short tripeptide fragment derived from the C‑terminal region of the endogenous peptide α‑melanocyte‑stimulating hormone (α‑MSH). In laboratory research, KPV is investigated as a signaling fragment capable of influencing inflammatory pathway models and melanocortin‑associated signaling systems. The peptide consists of three amino acids—lysine, proline, and valine—and is frequently used in experimental studies examining cellular signaling responses and peptide‑mediated regulatory pathways.

Because KPV represents a minimal bioactive fragment of α‑MSH, researchers use it as a molecular probe to evaluate how melanocortin‑derived peptide fragments interact with inflammatory signaling cascades and immune‑related cellular pathways under controlled laboratory conditions.

Mechanism of Action

In experimental models, KPV has been studied for its ability to influence cellular signaling pathways associated with inflammatory mediators. Research suggests that the peptide may interact with pathways involving nuclear factor‑kappa B (NF‑κB) signaling, a transcription factor complex involved in the regulation of inflammatory gene expression.

Investigations also evaluate KPV in the context of melanocortin signaling mechanisms related to α‑MSH peptide activity. Laboratory studies use KPV to explore how small peptide fragments derived from melanocortin hormones may influence cytokine signaling systems and immune‑associated cellular responses in controlled experimental environments.

Research Applications

• Inflammatory signaling pathway studies
• NF‑κB regulatory pathway research
• Melanocortin peptide fragment investigations
• Cellular immune signaling models
• Molecular biology studies involving α‑MSH derivatives

Chemical & Molecular Specifications

Compound name: KPV

Full name: Lys‑Pro‑Val

Peptide class: α‑MSH–derived tripeptide fragment

Sequence: Lys‑Pro‑Val

Molecular formula: C16H30N4O5

Molecular weight: 358.43 g/mol

Mono‑isotopic mass: 358.22 Da

CAS number: 67727‑97‑3

Typical analytical purity: ≥99%

Lyophilized Peptide

This peptide is supplied in lyophilized (freeze‑dried) form to support molecular stability during storage and transport. Lyophilization removes water under controlled conditions, helping preserve peptide structure and integrity prior to reconstitution for laboratory research applications.

Storage & Handling (Research Use Only)

• Store lyophilized material at -20°C or below unless otherwise specified by laboratory protocol.
• Following reconstitution, short‑term storage at 2–8°C is recommended.
• Protect from light and temperature extremes.
• Avoid repeated freeze‑thaw cycles.
• Handle using appropriate sterile laboratory techniques and institutional safety procedures.

References (Research Literature)

PubMed – α‑MSH derived peptides and inflammatory signaling

PubMed – NF‑κB regulation by melanocortin peptides

PubChem – KPV compound listing

ScienceDirect – melanocortin peptide signaling pathways

Research Disclaimer (EOC Labs)

RESEARCH USE ONLY.
This product is not intended for therapeutic, diagnostic, or clinical use. It is not a drug, food, cosmetic, or dietary supplement. EOC Labs products are sold strictly for laboratory research and analytical purposes only.

All information provided by EOC Labs, including descriptions, references,and technical data, is intended solely for educational and informational purposes. Statements have not been evaluated by the U.S. Food and Drug Administration (FDA). No claims are made regarding safety, efficacy, or suitability for any medical or consumer application.

By purchasing this product, the buyer certifies that it will be handled by qualified professionals in a properly equipped laboratory and used in compliance with all applicable local, state, and federal laws and regulations.